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pentobarbital will lower the extent or influence of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers may lead to lessened serum concentrations and loss of antimalarial efficacypentobarbital decreases levels of amphotericin B deoxycholate by inhibition of GI absorpti